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Cheapest SAMe (S-Adenosyl-L-Methionine) on iHerb

Ranked by real cost per 10 mg of SAMe (S-Adenosyl-L-Methionine) — cheapest value first.

Prices updated Jul 25, 2026 · 14 products · Prices in USD

The priciest option here costs about 77.8× more per 10 mg of SAMe (S-Adenosyl-L-Methionine) than the best-value pick Nutricost. For the same daily dose, choosing by cost per unit instead of sticker price can meaningfully cut your yearly spend.
#ProductDoseServingsPrice (USD)Cost per 10 mg
1
Nutricost, SAMe, 120 Capsules (200 mg per Capsule)
Nutricost, SAMe, 120 Capsules (200 mg per Capsule)
Nutricost
400 mg6035.950.015View on iHerb →
2
Nature's Craft, SAM-e, 200 mg, 60 Capsules
Nature's Craft, SAM-e, 200 mg, 60 Capsules
Nature's Craft
200 mg6019.990.017View on iHerb →
3
Nature's Craft, SAM-e, 150 mg, 90 Capsules
Nature's Craft, SAM-e, 150 mg, 90 Capsules
Nature's Craft
150 mg9024.990.019View on iHerb →
4
California Gold Nutrition, SAMe, Disulfate Tosylate, 400 mg, 60 Enteric Coated Tablets
California Gold Nutrition, SAMe, Disulfate Tosylate, 400 mg, 60 Enteric Coated Tablets
California Gold Nutrition
400 mg6046.660.019View on iHerb →
5
Swanson, SAMe, 60 Tablets (200 mg per Tablet)
Swanson, SAMe, 60 Tablets (200 mg per Tablet)
Swanson
400 mg3028.220.024View on iHerb →
6
California Gold Nutrition, SAMe, Butanedisulfonate, 400 mg, 60 Enteric Coated Tablets
California Gold Nutrition, SAMe, Butanedisulfonate, 400 mg, 60 Enteric Coated Tablets
California Gold Nutrition
400 mg6064.040.027View on iHerb →
7
Source Naturals, SAMe , 400 mg, 30 Enteric Coated Tablets
Source Naturals, SAMe , 400 mg, 30 Enteric Coated Tablets
Source Naturals
400 mg3033.520.028View on iHerb →
8
Doctor's Best, SAM-e, 200 mg, 60 Enteric Coated Tablets
Doctor's Best, SAM-e, 200 mg, 60 Enteric Coated Tablets
Doctor's Best
200 mg6033.990.028View on iHerb →
9
Source Naturals, SAMe, 60 Enteric Coated Tablets (200 mg per Tablet)
Source Naturals, SAMe, 60 Enteric Coated Tablets (200 mg per Tablet)
Source Naturals
400 mg3044.790.037View on iHerb →
10
Metabolic Maintenance, SAMe + Cofactors, 60 Vegetarian Capsules
Metabolic Maintenance, SAMe + Cofactors, 60 Vegetarian Capsules
Metabolic Maintenance
400 mg3073.000.061View on iHerb →
11
Pure Encapsulations, SAMe, 60 Capsules (200 mg per Capsule)
Pure Encapsulations, SAMe, 60 Capsules (200 mg per Capsule)
Pure Encapsulations
200 mg6084.500.070View on iHerb →
12
Seeking Health, Histamine Nutrients, 60 Capsules
Seeking Health, Histamine Nutrients, 60 Capsules
Seeking Health
100 mg3069.000.230View on iHerb →
13
Dr. Emil Nutrition, 5-HTP Plus with Co-Factor B6, 60 Capsules
Dr. Emil Nutrition, 5-HTP Plus with Co-Factor B6, 60 Capsules
Dr. Emil Nutrition
20 mg3023.690.395View on iHerb →
14
Dr. Emil Nutrition, Elite, 5-HTP Plus with Co-Factor B6, SAMe, Magnesium, & Kava Root, 60 Capsules
Dr. Emil Nutrition, Elite, 5-HTP Plus with Co-Factor B6, SAMe, Magnesium, & Kava Root, 60 Capsules
Dr. Emil Nutrition
10 mg3034.951.17View on iHerb →

How we rank SAMe (S-Adenosyl-L-Methionine)

Two supplements can list the same dose per serving yet cost very differently once you account for how many servings are in the bottle. We calculate the total nutrient in each container (dose per serving × servings per container), divide the current price by that total, and rank by the resulting cost per unit. Lower is better. Because prices are refreshed automatically, this ranking reflects today's iHerb pricing rather than a snapshot from months ago.

Cost per unit is a starting point, not the whole story — the ideal form, third-party testing, and other ingredients matter too. Always check the label and consult a healthcare professional before starting a supplement.

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Prices update automatically and may differ from iHerb at checkout. Rankings are based on cost per unit of the listed nutrient and are for informational purposes only — not medical advice. Links to iHerb are affiliate links.